miR‐144/451 inhibits c‐Myc to promote erythroid differentiation
نویسندگان
چکیده
منابع مشابه
miR-150 inhibits terminal erythroid proliferation and differentiation
MicroRNAs (miRNAs), a class of small non-coding linear RNAs, have been shown to play a crucial role in erythropoiesis. To evaluate the indispensable role of constant suppression of miR-150 during terminal erythropoiesis, we performed miR-150 gain- and loss-of-function experiments on hemin-induced K562 cells and EPO-induced human CD34+ cells. We found that forced expression of miR-150 suppresses...
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Purpose: Yolk sac hematopoietic stem cells (YS-HSC) have two dominant characteristices: a larger reproductive capacity and the absence of the expression of MHC associated antigens. Therefore, these cells are promising candidates for transplantation, cell therapy and gene manipulation. There are controversial reports on the effects of erythropoietin (EPO) on the differentiation of yolk sac cells...
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The most striking molecular event during erythroid differentiation is the accumulation of haemoglobin but this is only one of many overt changes which occur in the maturing erythroid cell. Other proteins accumulate progressively, notably carbonic anhydrase and catalase while yet others, particularly the enzymes of haem synthesis, such as aminolaevulinic acid synthetase, accumulate during early ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2020
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.202000941r